Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Synthesis and antitubercular activity of isoniazid condensed with carbohydrate derivatives

Blog Article

A series of 13 compounds analogous of isoniazid condensed with carbohydrate was synthesized and Keyrings evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and the activity expressed as the minimum inhibitory SENSITIVE HAIR$SCAPL SHAMPOO concentration (MIC90) in μg/mL.Several compounds exhibited antitubercular activity (0.31-3.12 μg/mL) when compared with first line drugs such as isoniazid (INH) and rifampicin (RIP) and could be a good starting point to develop new compounds against tuberculosis.